Proteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility in yeast

A number of protein complexes are destabilized in probably the most faulty alternative traces, 16L and eight+15L

Our genetic experiments and protein complicated correlation evaluation prompt that unstable chimeric protein complexes are the main explanation for proteotoxic stress underlying complicated incompatibilities. To immediately check the “unstable complicated” speculation, we characterised native protein complicated formation in probably the most faulty alternative traces, 8+15L and 16L, and in contrast it with the parental Sc pressure. We predicted that the alternative traces ought to show extra unstable protein complexes than Sc and these can be enriched with subunits encoded by changed Chromosomes 8, 15, and 16.

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