What causes ESR induction in our chromosome alternative traces? Research in aneuploid cells counsel that ESR might be induced intrinsically by the proteotoxic stress arising from unbalanced chromosome numbers40,41. Notably, the ESR signature in our alternative traces was considerably correlated to that noticed for an aneuploid inhabitants (ρ = 0.41, p < 2.23 × 10−16, Spearman’s rank correlation, Supplementary Information 2)42. Nevertheless, the alternative traces are euploid and derived from associated yeast species with an virtually full set of orthologous proteins. Thus, the reason for ESR in hybrid alternative traces is more likely to be completely different from that in aneuploid strains.
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