As anticipated, the α-syn unfold inside the substantia nigra by one month following injection, and at six months from injection, about half the dopaminergic neurons had been misplaced in these mice. In distinction, irisin rescued these neurons, with solely a 25% loss in comparison with 60% when the identical viral vector was injected with out irisin.
The enzyme and transporter concerned in dopamine transmission on this area have been rescued nonetheless extra considerably. Although their ranges dropped by half within the mice injected with α-syn PFF, this was restored to simply 6% lower than regular by irisin injection. Irisin additionally prevented a lower within the dopamine/dopamine metabolites by 70% to 95%, relying on the compound measured, with dopamine turnover being suppressed.
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