This array of compositional area with totally different nucleotides have been reported to be associated to totally different organic options in lots of organisms. Due to this fact, adjustments in genome heterogeneity could be helpful for evolutionary and epidemiological research, as they’ll reveal the adaptive means of CoVs to the human host.
A brand new research printed on the preprint server bioRxiv* used the Sequence Compositional Complexity (SCC) to measure genome heterogeneity by means of the assistance of a correct segmentation algorithm. The research additionally makes use of phylogenetic ridge regression to disclose a long-term tendency of decreased genome sequence heterogeneity in SARS-CoV-2.
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