Why fatigue from long COVID goes beyond simply feeling tired

Fatigue is essentially the most reported symptom, with 41% to 60% of sufferers experiencing debilitating fatigue past six months and even as much as a yr. This long-lasting fatigue can be a attribute of post-infectious syndromes from different pathogens such because the micro organism Coxiella burnetii and the Epstein-Barr virus that causes mononucleosis. Persistent fatigue syndrome (CFS), or myalgic encephalomyelitis (ME), additionally ends in extreme fatigue for six months or extra, accompanied by diminished health and cognitive impairment.

Analysis has recognized a connection between CFS-related fatigue and a rise in cytotoxic T-lymphocytes and cytokines. Current research have additionally discovered a rise in T- and B-lymphocytes and inflammatory cytokines in sufferers convalescing from COVID-19. Nevertheless, a complete scientific and immunologic profiling of lengthy COVID sufferers associating immunological abnormalities with the scientific manifestations of lengthy COVID is missing.

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