$$D({{bf{p}}}^{{rm{W}}{rm{T}}}to {{bf{p}}}^{{rm{M}}{rm{T}}})=(1-w)log ,left(frac{{Okay}_{{rm{d}}}^{{rm{W}}{rm{T}}}}{{Okay}_{{rm{d}}}^{{rm{M}}{rm{T}}}}proper)+w,log ,left(frac{{{rm{E}}{rm{C}}}_{50}^{{rm{M}}{rm{T}}}}{{{rm{E}}{rm{C}}}_{50}^{{rm{W}}{rm{T}}}}proper),$$
(1)
the place (w) units the relative weight between the 2 phrases. We selected the parameters of the neoantigen high quality mannequin to maximise the log-rank check rating of survival evaluation on an unbiased cohort of 58 sufferers with PDAC5 (Supplementary Methods and Prolonged Knowledge Desk 1a).