“If that’s the case,” Kim stated, “then we will proceed to make use of them in therapeutics and we received’t have to fret as a lot about them making the fallacious protein.”
The interpretation of the genetic code into practical protein is a feat completed in all domains of life by the ribosome. The Zaher lab conducts analysis that expands our understanding of the mechanisms that govern translational fidelity on the ribosome and the impression of those mechanisms on mobile health.
On this specific research, the Zaher lab researchers used a number of experimental techniques to check the results of N1-methylpseudouridine on translation. They discovered that N1-methylpseudouridine is learn precisely by the ribosome. Additionally they discovered that mRNAs containing N1-methylpseudouridine didn’t seem to make miscoded proteins extra ceaselessly than mRNAs containing unmodified nucleotides.
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