“There’s been an enormous explosion in curiosity in using therapeutic mRNAs for a lot of totally different illnesses,” Kim stated. “This paper provides extra confidence that therapeutic mRNAs aren’t going to make proteins they weren’t supposed to make.”
Kim et al., N1-methylpseudouridine discovered inside COVID-19 mRNA vaccines produces devoted protein merchandise, Cell Experiences (2022), https://doi.org/10.1016/j.celrep.2022.111300
Funding: This work was supported by a grant from the Nationwide Institutes of Well being (NIH) (R01GM141474).
The authors thank the Alvin J. Siteman Most cancers Heart at Washington College College of Medication and Barnes-Jewish Hospital and the Institute of Scientific and Translational Sciences (ICTS) at Washington College in St. Louis for using the Genome Expertise Entry Heart, which offered sequencing providers for this research.