In adults, there may be concern of the buildup of extra fluoride in bones which will enhance the chance of fractures. Analysis has proven blended outcomes, from a constructive affiliation, to no affiliation, to even a protecting impact of fluoride. A meta-analysis taking a look at 13 cohort research didn’t discover an affiliation of publicity to fluoride from consuming water (starting from 7 to 44 years) and an elevated danger of hip fractures in older adults. [13] The authors famous potential confounding elements, similar to elevated calcium complement use on this age group, which may lower fluoride absorption. Bone formation additionally decreases with age, so much less fluoride is absorbed and wanted by bone tissue. In distinction, a cohort examine revealed in 2021 trying on the affiliation of fractures in postmenopausal ladies and fluoride as measured in urine and dietary intakes discovered greater charges of hip fractures when evaluating the very best to lowest intakes of fluoride and urinary fluoride. The imply dietary consumption was about 2 mg day by day that included consuming water fluoridated at about 1 mg per liter. [14] With these inconclusive findings, extra giant research are wanted on this space.
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