If the complicated instability is because of incompatibility between S. cerevisiae and S. bayanus var. uvarum protein subunits (i.e., species-specific interactions), we anticipated that the complexes having subunits encoded by overseas Chromosomes 8, 15, and 16 ought to be much less steady than these missing such subunits. Certainly, Chr8+15 and Chr16 complicated proteins (i.e., proteins from the complexes containing subunits from Chromosomes 8+15 and 16, respectively) offered considerably increased EPD values in comparison with non-Chr8+15 and non-Chr16 complicated proteins (i.e., proteins from the complexes missing any Chromosome8+15-encoded and 16-encoded subunit, respectively) (adjusted p-values = 1.0 × 10−10 (Sc/8+15L) and three.1 ×10−4 (Sc/16L), Fig. 3b, Supplementary Fig. 6a, b). Moreover, there was no vital distinction between the EPD values of non-Chr8+15 and non-Chr16 complexes and non-complex proteins, respectively (adjusted p-values = 1 (Sc/8+15L) and 0.06 (Sc/16L)). Thus, the presence of overseas complicated subunits was probably the first contributory issue for the instability of protein complexes in 8+15L and 16L cells.
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